As the particles are often pseudotyped with the envelope of the vesicular stomatitis virus (VSV), the vector can serve to introduce genes into a broad range of tissues and can be used in vivo.

Current lentiviral vector systems (the third generation) generate virus particles using four plasmids and a producer cell line. The rationale behind four plasmids is to enhance safety, as ...

researchers used a lentiviral vector to deliver gene therapy to five patients with hemophilia A. After treatment, all five had stable levels of factor VIII in their blood, with no serious safety ...

VectorBuilder's partner, Ucello, announced that its CD19-targeting umbilical cord blood-derived allogeneic CAR-T cell therapy ...

senior vice president of process and analytical development at viral vector manufacturer iVexSol, which uses its lentiviral vector technology to reduce the time and expense involved in cell and ...

X-linked sideroblastic anemia (XLSA) is a rare genetic disorder caused by mutations in the ALAS2 gene, which plays a critical role in heme biosynthesis within red blood cells.

and protects mice against two different influenza strains in lethal challenge experiments. These data suggest that rSIV.F/HN could be used as a vector for passive immunisation against influenza and ...

SAN DIEGO -- Results from a small single-center study showed that treatment with a gene therapy involving the use of lentiviral vector-transduced autologous hematopoietic stem cells (HSCs ...

1 Fujian Provincial Key Laboratory of Cardiovascular Disease, Affiliated Fujian Provincial Hospital, Fujian Medical University 2 Emergency Center of Fujian Province, Affiliated Fujian Provincial ...

Its multi-platform development approach applies the lentiviral vector and adeno-associated viral vector gene therapy platforms. Its clinical program is an LVV-based gene therapy for the treatment ...