For example, 45 human protein kinases lack at least one of the conserved catalytic residues 2 and may not have kinase activity. Kinase activity has not been detected for several CDK-related ...

Among these, RAF1 S257, S259, G361, and R391 mutations are oncogenic or likely oncogenic mutations that confer increased kinase activity. 35 Conversely, among 66 class 3 MAP2K1-mutated tumors, no RAF1 ...

A creatine kinase test is a blood test that measures ... The amount of CK in the blood is reported in units (U) of enzyme activity per liter (L) of serum. Normal CK levels vary depending on ...

Researchers from the Nagoya University Graduate School of Medicine identified an enzyme, alpha-kinase 2 (ALPK2) that is ...

Erlotinib is a quinazoline derivative that selectively and reversibly inhibits the tyrosine kinase activity of the EGFR. Here, we review the mechanism(s) of action of erlotinib, as well as the ...