Colon cancer is the third leading cause of cancer-related deaths worldwide, posing a significant global health challenge.

They found that the inner lining of the upper intestine, called the "epithelium" –composed of a variety of cells that are not classically part of the immune system – also plays an active role ...

The epithelial lining of our intestine is organized in a crypt-villi architecture and serves many essential functions including maintenance of barrier, digestion and nutrient absorption. Due to the ...

In vivo, the intestinal epithelium interacts with the neighboring environment through complex crosstalk, which involves components such as the immune system, tissue microenvironment, and gut microbes.

These cultures are derived from stem cells isolated from human intestinal tissue. The stem cells are propagated in vitro and form mature intestinal epithelium upon growth factor manipulation. In order ...

Barrett's esophagus is an acquired metaplastic abnormality in which the normal stratified squamous epithelium lining of the esophagus is replaced by an intestinal-like columnar epithelium.

Intestinal organoids that are classically grown in 3-D matrices are cystic, which means that they have a monolayer of epithelial cells with fluid inside. The cells interact with the matrix on the ...