We have identified four genetic variants that confer reduced β-cell exocytosis and six variants that interfere with insulin granule distribution. Based on these observations, we calculate a ...

In addition, N1I5 pancreatic β cells displayed an approximately 50% reduction in insulin exocytosis and a lower percentage of insulin granules were docked at the plasma membrane, suggesting ...

Despite the clear difference in insulin secretion between islets from T2D and non-T2D donors, there was no overall change in β-cell exocytosis between the two groups (Fig. 1B). T2D may result ...