CRISPR’ing human iPSCs allows researchers to manipulate genes to study their functions in the context of specific diseases, or to correct genetic defects in patient cells. One challenge that seamless ...

该研究对用于 CRISPR 基因编辑治疗的 Cas 核酸酶 SaCas9 和 AsCas12a 进行了理性工程化改造，设计出了具有最小化免疫原性的 SaCas9 和 AsCas12a 突变体。

iPSC-based therapies could replace ... to sense their environment and act only if certain conditions are met. “CRISPR gene-editing technology,” Ettenberg says, “allows us to modify the ...

Use Applied StemCell's (ASC) new GMP facility, comprised of five cleanrooms equipped with cutting-edge technology, to develop the next generation of iPSC-derived therapeutics. We have dedicated ...

Using CRISPR, the team then individually modified each imprinting site to shut down the ... Helmed by Katsuhiko Hayashi at Osaka University, a team of scientists leveraged a curious quirk of iPSC ...

The discovery of the CRISPR/Cas9 system has transformed research and now allows straightforward alterations in the genome and can be exploited to introduce changes to mimic diseases. This presentation ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

Moreover, we can transplant these cultures into the mouse brain. We also combine iPSC-derived endothelial cells, pericytes and astrocytes for modelling blood-brain barrier. The impact of mutations and ...

bit.bio’s ioCells are human iPSC-derived cells manufactured using the company’s deterministic cell programming ... they facilitate a deeper understanding of intracellular interactions in disease.