Hypoxic cells can acquire a mutator phenotype that consists of decreased DNA repair, an increased mutation rate and increased chromosomal instability. Defects in homologous recombination and ...

Beall has been studying the human response to hypoxic living conditions for years. In research published in October 2024, she ...

Hypoxia-driven gene and protein changes enhance epithelial-to-mesenchymal transition, remodel the extracellular matrix, drive drug resistance, support cancer stem cells and aid evasion from immune ...

Hypoxia, a condition characterized by reduced oxygen availability, has been widely studied for its potential therapeutic ...

Researchers will explore a promising approach for treating degenerative diseases by replacing damaged cells with new ones and ...

Strictly speaking, radiosensitizers shouldn't have inherent cytotoxic activity. The hypoxic cell sensitizers (e.g. misonidazole), and thymidine analogs (e.g. bromodeoxyuridine) are examples of ...

Yet for decades the precise workings were largely a mystery. Scientists knew that in low oxygen situations, or hypoxia, cells trigger a cascade of physiological events to restore oxygen ...

This hypoxic zone is created by the substantial consumption of oxygen by rapidly proliferative tumor cells. Hypoxic zones are known to be resistant to most therapies, including radiotherapy.

"However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis in T cells." The UAB researchers found that HIF1α-glycolysis is indispensable for ...

By lowering the media volume, and thus increasing the pericellular oxygen, Tan observed lowered hypoxia signaling and transcriptional rewiring that recapitulated a healthier adipocyte cell model.