Hypoxic cells can acquire a mutator phenotype that consists of decreased DNA repair, an increased mutation rate and increased chromosomal instability. Defects in homologous recombination and ...

Hypoxia, a condition characterized by reduced oxygen availability, has been widely studied for its potential therapeutic ...

Hypoxia-driven gene and protein changes enhance epithelial-to-mesenchymal transition, remodel the extracellular matrix, drive drug resistance, support cancer stem cells and aid evasion from immune ...

"However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis in T cells." The UAB researchers found that HIF1α-glycolysis is indispensable for ...

This hypoxic zone is created by the substantial consumption of oxygen by rapidly proliferative tumor cells. Hypoxic zones are known to be resistant to most therapies, including radiotherapy.

Strictly speaking, radiosensitizers shouldn't have inherent cytotoxic activity. The hypoxic cell sensitizers (e.g. misonidazole), and thymidine analogs (e.g. bromodeoxyuridine) are examples of ...

Yet for decades the precise workings were largely a mystery. Scientists knew that in low oxygen situations, or hypoxia, cells trigger a cascade of physiological events to restore oxygen ...

Over the past two decades, intermittent hypoxic training (IHT), that is, a method where athletes live at or near sea level but train under hypoxic conditions, has gained unprecedented popularity. By ...

Pancreatic cancer has the worst survival rates among all solid tumor types, and its incidence is increasing. Hypoxic conditions that arise from an imbalance between increased oxygen consumption and an ...

Ozone (O3) exposure may reduce the availability of oxygen in the body, resulting in arterial stiffening due to the body's natural response to create more red blood cells and hemoglobin, according to a ...