Leptin, a hormone synthesized primarily by adipose tissue and secreted into the circulatory system, is a purported satiety factor with receptors in the hypothalamus. Human leptin is a relatively small ...

In humans, many leptin deficiency syndromes are responsive to leptin replacement therapy. As leptin is involved in numerous pathways, the effects of too little leptin are widespread (including ...

CIRM awards US$ 4 mn grant to Entos Pharma to advance development of ENTLEP001, a durable and redosable genetic medicine to treat CGL: San Diego Friday, February 7, 2025, 15:00 Hr ...

Figure 1: Leptin-induced reduction in food intake and body weight is attenuated by D-Phe CRF. Because effects of leptin were attenuated but not abolished by the CRF receptor antagonist ...

A hormone present in the human body could be used to stop early ... that a small part of an appetite-suppressing hormone called leptin, which is present in everyone, can have dramatic effects ...