Prion disease is a neurodegenerative disorder caused by the accumulation and misfolding of prion protein (PrP ... or the most common mutation in genetic prion disease. By the study endpoint ...

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends ...

Furthermore, studies on genetic prion diseases have revealed ... Prion: A type of infectious agent composed of protein that can cause neurodegenerative diseases by inducing abnormal folding ...

Protein aggregation is typical of neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team headed by Professor Jörg Tatzelt from ...

Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: Implications for prion diseases. Proceedings of the National Academy of Sciences , 2024; 122 (1 ...

Explorations of toxic protein species via genetic disease ... If so, PrP C contributes to neurotoxicity in prion disease but by uncertain mechnisms.

"Prion disease has a lot of different origins - some are genetic, some occur spontaneously ... be used to disrupt the gene encoding the prion protein. Minikel remembers thinking, "There's ...

“Prion disease has a lot of different origins — some are genetic, some occur spontaneously ... used to disrupt the gene encoding the prion protein. Minikel remembers thinking, “There ...

Researchers at Ruhr University Bochum discovered that a lipid anchor on nerve cell membranes stabilizes prion protein folding, preventing harmful aggregation linked to prion diseases. Their in vitro ...

A research team from University of Tsukuba performed a large-scale genome analysis of Japanese and European populations and discovered gene regions (genetic ... for prion disease that extends ...