Scientists at the University of São Paulo analyzed blood samples donated by six serodiscordant couples where female partners ...

Researchers discovered that ALPK2, a heart-specific enzyme, may protect against HFpEF by activating TPM1 in heart muscle ...

Background: Variable rates of HER2 protein overexpression and gene amplification have been reported in advanced ovarian cancers (AOC). Trastuzumab, tested only as a single agent, has been shown to ...

Background and aims The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development. Although SOX9 has been implicated in ...

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem ...

Supporting the role of ZIC1 mutations as true driver events of medulloblastoma, the researchers found that overexpression of ZIC1promotes malignancy in SHH medulloblastoma precursor cells.

These findings raise the question of whether retroviral VEGF gene therapy is useful for therapeutic ‘angiogenesis’ without risking ‘angioma-genesis’. Overexpression of VEGF may lead to an ...

Heart failure with preserved ejection function is a lethal form of heart failure, with few effective treatments. A team from ...