Scientists at the University of São Paulo analyzed blood samples donated by six serodiscordant couples where female partners ...

Background and aims The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development. Although SOX9 has been implicated in ...

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem ...

Background: Variable rates of HER2 protein overexpression and gene amplification have been reported in advanced ovarian cancers (AOC). Trastuzumab, tested only as a single agent, has been shown to ...

These findings raise the question of whether retroviral VEGF gene therapy is useful for therapeutic ‘angiogenesis’ without risking ‘angioma-genesis’. Overexpression of VEGF may lead to an ...

The gene BATF3 was identified as a particularly impactful master regulator, the overexpression of which seemed promising for the improvement of T-cell function. To test the potential of BATF3, the ...