Our data also provide clues to biological function for hundreds of ... of which cause DNA damage and consequent cell-cycle arrest at multiple checkpoints. DNA-damage experiments were performed ...

Other proteins act to hold the cell at distinct points in the cycle (checkpoints ... many proteins have important functions in other aspects of the cell cycle; one is replication of DNA and ...

which implies that these cells are capable of bypassing cell cycle checkpoints and regulation by tumor suppressor signaling pathways. Aberrant chromosome segregation generates aneuploid cells and ...

NK cells’ metabolism, proliferation, survival, and cytotoxic function are all impacted by intracellular checkpoint molecules such as FBP-1, EZH2, CIS, TIPE2, and HIF-1α, which significantly ...