Frizzled (FZD) receptors are key players in a pathway called Wnt that promotes malignant cell growth, making them a promising ...

Using three different mutagenesis strategies coupled with a cell-surface binding assay, the authors identified a number of residues in the Frizzled 8 CRD that, when mutated, disrupt Wnt binding ...

Signaling is initiated by the binding of Wnt to a Frizzled receptor as well as a low-density lipoprotein receptor-related protein (LRP) coreceptor (e.g., LRP5) but is inhibited by the binding of ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...