This pathway is involved in a variety of normal ... the authors identified a number of residues in the Frizzled 8 CRD that, when mutated, disrupt Wnt binding (shown in red for one of the monomers).

Frizzled (FZD) receptors are key players in a pathway called Wnt that promotes malignant cell growth, making them a promising ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...