However, the biopsy procedure itself and the need to expand fibroblasts in culture still represent major hurdles to be overcome before the iPS cell technology can become more broadly applicable.
Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast function as well as immune suppression ... including mouse models of pancreatic cancer, ...
Teasing apart their specific functions is crucial for developing appropriate treatments, Santi said. Fibroblasts can switch between phenotypes, and the methods used by scientists to isolate and ...
Pancreas cells may produce a protein that can protect the brain from Alzheimer's disease. In individuals with Alzheimer's disease, a peptide known as amyloid-β accumulates and forms tangled plaques.
Cancer-associated fibroblasts (CAFs), notably those ... determined the impact of PROX1 overexpression on CRC cell properties, while co-culture experiments spotlighted the PROX1-CAF relationship.