New in vivo evidence confirms that tumor-expressed Fas ligand impairs immune responses to cancer by inducing apoptosis of anti ... cells transiently upregulated FasL when grown in the peritoneal ...

was identified as a crucial component not only of Fas-mediated, but also of TNF and TNF-related apoptosis-inducing ligand (TRAIL)-triggered caspase-independent cell death. Figure 1: FasL-induced ...

Metabolic stress causes an increased Fas-FasL (receptor-ligand pair) expression in Neural Stem Cells (NSCs) leading to Fas-induced apoptosis. In this study, we discuss the exposure of NSCs to ...

CONCLUSION Fas/FasL interaction is probably implicated in the human CF airway apoptotic pathway. The mechanisms of induction of FasL expression and its role in inducing tissue damage or remodelling or ...

Blocking and agonistic antibodies were used to define the role of Fas-mediated apoptosis in B cell regulation. Results Treg failed to restrain B cell activation, proinflammatory cytokine and antibody ...

Mcmaster.ca Background and aims: Mucosal flattening and epithelial cell apoptosis are typical features of T cell induced inflammatory ... assay. The role of perforin, Fas/Fas ligand (FasL), tumour ...

Fas ligand (FasL) is a molecule that induces Fas receptor mediated apoptosis of activated immunocytes, thereby mediating normal immune downregulatory roles including immune response termination, ...

In this review, we discuss the development of proapoptotic drugs and their clinical efficacy. Figure 1 Tumour cells undergoing apoptosis. The TNF gene superfamily includes TNF, FAS ligand (FASL), and ...

According to reviewed ALPS criteria, the lymphocyte apoptosis defects detection and somatic or germline mutation identification (FAS, FASL, or CASP10 genes) are primary additional criteria (box 1).

He is a member of the National Academy of Science. Shigekazu Nagata's laboratory identified Fas ligand (FasL) and its receptor (Fas) and proposed that apoptosis can be triggered by a death factor. He ...