In each case the inhibiting anti-human Factor VIII antibody was added to block the endogenous Factor VIII activity. Using immobilized Factor XIIa, human, bovine, and guinea pig plasmas showed the ...

He says Bayer is only able to recover 1/1000 th the level of the typical antibody or cytokine expressed in mammalian cells because the size of factor VIII makes it exquisitely sensitive to ...

for severe haemophilia A in adults without inhibitors – antibodies that make standard Factor VIII replacement medicines less effective. Patients should also not antibodies to the adeno ...

Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels. He was worked up for causes of acquired haemophilia A and was found to ...

addressing the exclusion of patients with preexisting anti-AAV antibodies. Severe hemophilia A is caused by a genetic absence or variant in genes needed to produce blood-clotting factor VIII ...

Her abdomen was open for 5 days. She was treated with activated recombinant human factor VIIa to bypass inhibited factor VIII, and with immunosuppression using steroids, cyclophosphamide and anti-CD20 ...