Formation of the 3′ end of histone mRNA. The genes encoding metazoan canonical histones lack introns, and thus an endonucleoytic cleavage that releases the nascent pre-mRNA from the DNA template ...

Histone chaperones have an important role in controlling histone dynamics at the fork. The maintenance of DNA methylation and histone modifications is interconnected at the replication fork.

Aging involves complex cellular and molecular changes, including epigenetic modifications like Deoxyribonucleic acid (DNA) methylation and histone marks. Age predictors, or "clocks," have been ...

This enzyme is able to silence specific DNA sections by epigenetically modifying histone proteins that package the DNA. These modifications ensure that the DNA is densely packed as heterochromatin ...

In a preprint uploaded to bioRxiv this January that has yet to undergo peer review, the team describes hundreds of potential histone proteins in bacteria, including one that they predict interacts ...

The basic organizational unit of the genome is a nucleosome, which is a short segment of DNA wound around a complex of eight histone subunits. Each of these histones has a tail region which can be ...

Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone packaging proteins, to establish and maintain cell identity and fate. We develop and ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

Results prove that inversions can be generated in plants without causing further unwanted changes in the expression of genetic information.

Researchers uncover a link between genetic mutations and epigenetic changes, two major contributors to aging. Their findings ...

Epigenetics is the study of heritable changes in gene expression that do not involve alterations to the DNA sequence. Epigenetic modifications, such as DNA methylation and histone modifications, can ...