This revealed that the DNA-binding domain of Nr5a2 competes with a DNA minor groove anchor of the nucleosome and partially unwinds the DNA from the histones. "You can imagine it as if Nr5a2 were ...

A nucleosome is a section of DNA that is wrapped around a core of proteins. Inside the nucleus, DNA forms a complex with proteins called chromatin, which allows the DNA to be condensed into a ...

These dual-labeled hydrolysis probes consist of a 5' fluorescent reporter dye and a 3' Eclipse Dark Quencher (EDQ) coupled to the minor groove binder (MGB ... purified (B) DNA gave clear clusters ...