来自MSN11 个月
Hooking an anchor on the DNA minor groove to facilitate gene expression during reprogramming
This revealed that the DNA-binding domain of Nr5a2 competes with a DNA minor groove anchor of the nucleosome and partially unwinds the DNA from the histones. "You can imagine it as if Nr5a2 were ...
Nature8 天
Minor Groove Binding Compounds in DNA Recognition
Another important aspect of recent research is the thermodynamic analysis of minor groove binders. Studies have shown that the binding of designed synthetic agents to DNA is influenced by the ...