Clearly, the MMR hMSH2–hMSH6 heterodimer provides an important DNA damage signal for colorectal, endometrial and ovarian cells, and mutations in either of these genes leads to ineffective ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

The finding provides a new understanding of a new type of cell signaling that may lead to ... mechanisms of NF-κB activation in response to DNA damage.” The researchers discovered that UV ...

Our cells use oxygen to generate energy by burning nutrients to keep various processes in the cell working. While making this energy in the mitochondria (the cell’s power plants), the cell also ...

including signaling modulation and DNA repair. PARylation is reversible and is undone by PAR erasers such as poly ADP-ribose glycohydrolase (PARG). This serves two main functions. First, it allows ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

Spending enough time in the sun without adequate protection can leave us looking and presumably feeling like a lobster ready for the plate.

Their results suggest that DNA damage itself serves as the checkpoint ... "The hypothesis that such breaks themselves are a regulatory signal, rather than simply an obligate intermediate of ...

Chair, Molecular Biology Program, SKI; Director, The Functional Genomics Initiative; Paul A. Marks Chair in Molecular Cell Biology Scientists know that cancer can result from mistakes in DNA repair.

"DNA damage is serious as the mutations will get ... leading to inflammatory signaling and recruitment of immune cells, which then leads to inflammation of the skin. "We found that the first ...