Even the universal and generally successful cystic fibrosis (CF) carrier screening ... than back-of-the-envelope estimates based solely on allele frequencies. Such is the case for the variant ...

CFTR: Cystic fibrosis transmembrane conductance regulator, a protein that regulates salt and water transport in cells. F508del allele: A common mutation in the CFTR gene associated with cystic ...

In example 2, only one parent (the father) has a copy of the recessive allele (Ff). There is no chance of them producing a child with cystic fibrosis. However, half the possible offspring will be ...