Whole body total cholesterol synthesis was not changed but bile-acid synthesis appeared to be stimulated, suggesting that KB2115 may act to induce net liver cholesterol removal. Previous studies ...

Now, cancer biologists at the Salk Institute have discovered that PIN1 is a significant driver of bladder cancer and revealed that it works by triggering the synthesis of cholesterol—a membrane ...

Reduced receptor-mediated catabolism of LDL causes high plasma LDL cholesterol (LDL-C ... ezetimibe and bile acid sequestrants. In untreated HoFH, coronary heart disease usually develops in ...

2019;12a] Statins — inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, a key enzyme in cholesterol synthesis ... PCSK9 inhibitors, and bile acid sequestrants — to maximally ...

Diacylglycerol acyltransferase (DGAT) is an enzyme that catalyzes the final step in TG synthesis ... Docosahexaenoic acid; EPA: Eicosapentaenoic acid; HDL-C: HDL cholesterol; LDL-C: LDL cholesterol.