Whole body total cholesterol synthesis was not changed but bile-acid synthesis appeared to be stimulated, suggesting that KB2115 may act to induce net liver cholesterol removal. Previous studies ...

More information: Li T, Hasan MN, Gu L. Bile acids regulation of cellular stress responses in liver physiology and diseases, ...

necessary for the synthesis of triglycerides and cholesterol esters—which accumulate pathologically in the liver in SLD—and also for bile acids, which favors the elimination of cholesterol ...

Reduced receptor-mediated catabolism of LDL causes high plasma LDL cholesterol (LDL-C ... ezetimibe and bile acid sequestrants. In untreated HoFH, coronary heart disease usually develops in ...