The Falke group is currently investigating the molecular mechanisms of on-off switching of components within the chemosensory array, especially the mechanisms by which transmembrane receptors bind ...

CD14 and the Fcγ receptors CD32 and CD64 belong to a group of cell surface receptors engaged in phagocytosis by various types of phagocytes, including macrophages, dendritic cells and monocytes 14.

Adhesion G protein-coupled receptors (GPCRs) are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for ...

A team led by UT Southwestern scientists has discovered a mechanism that promotes metastasis in pancreatic, breast, and ...

A new twist on a decades-old anticancer strategy has shown powerful effects against multiple cancer types in a preclinical ...

Researchers analyzed the heart cells for cell-surface receptors that are associated with the three pathways, and they looked for differential extracellular protein expression of proteins that interact ...

Pleil refers to as “front-loading.” Surprising Discovery: Cell-surface Receptors Allow Estrogen to Act Fast Although the researchers suspected estrogen would have an effect on drinking ...

The cryo-EM images showed that the GAIN domain of the receptor assumed several different positions in relation to the cell surface. Each different position of the GAIN domain created a different ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists have ...

A “checkpoint” receptor that often resides on the surface of immune system cells, the PD-1 molecule works as a type of off switch that keeps immune cells from attacking other cells.

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...