New research has identified the Rho GTPase target ROCK-I as being cleaved by caspases during apoptosis. ROCK-I is known to stimulate actomyosin-based contractility. Once cleaved, ROCK-I is ...

Four murine CMV genes are involved in regulating murine CMV-induced apoptosis. These include the gene that encodes M36, which interacts and prevents the activation of pro-caspase 8, the initiator ...

Scientists use cell death, whether by apoptosis or necrosis, to evaluate the toxicity or effectiveness of substances of interest, including potential therapeutic agents. For example, researchers will ...