You have full access to this article via your institution. Though activation of the calcineurin pathway can produce cardiac hypertrophy in transgenic mice 3, the results of our study indicate that ...

Another promising avenue of research involves the development of novel inhibitors targeting the calcineurin-NFAT signaling pathway, particularly in the context of cancer. For instance, a new non ...

Several investigators have attempted to test the effects of one or more SNPs on patients’ response to calcineurin inhibitors ( Table 1).

One contributing factor to the inconsistent pharmacokinetics of calcineurin inhibitors may be variable expression of functional CYP3A4 enzymes, CYP3A5 enzymes, and PGP efflux pumps. The ...

Among nearly 600 children, there was no significant difference in time to relapse between those taking a calcineurin inhibitor compared with those taking cyclophosphamide (HR 1.25, 95% CI 0.84-1. ...