You have full access to this article via your institution. Though activation of the calcineurin pathway can produce cardiac hypertrophy in transgenic mice 3, the results of our study indicate that ...

Another promising avenue of research involves the development of novel inhibitors targeting the calcineurin-NFAT signaling pathway, particularly in the context of cancer. For instance, a new non ...

Among nearly 600 children, there was no significant difference in time to relapse between those taking a calcineurin inhibitor compared with those taking cyclophosphamide (HR 1.25, 95% CI 0.84-1. ...

Long-term toxicity is of concern. Calcineurin inhibitors (cyclosporine and tacrolimus) are effective in SSNS but at the price of calcineurin-dependency with potential side effects; therefore ...

Several investigators have attempted to test the effects of one or more SNPs on patients’ response to calcineurin inhibitors ( Table 1).

Belatacept, a biologic, is an immunosuppressant that offers an alternative to conventional drugs like calcineurin inhibitors with less nephrotoxicity. Solid organ transplant immunosuppressants are ...