Here we initially performed a detailed analysis of T cells expressing B7-H3-CARs with different hinge/transmembrane (CD8α vs CD28) and CD28 or 41BB costimulatory domains (CD8α/CD28, CD8α/41BB, ...

Cancer immunotherapy has represented a significant advancement in cancer treatment; however, many patients experience relapse or develop resistance to this treatment. Bispecific antibodies that ...

No significant differences were present between the groups regarding age (Table 1). There was no significant age difference between 6 newly diagnosed HT patients (mean 12.3 ± 1.9 years) and the ...

To stimulate thymocytes or T cells, cells were incubated with stimulating monoclonal antibodies to CD3, Ti or CD28 at 4 °C for 15 min, washed with cold PBS to remove nonbinding antibodies and ...

(1) T cells are isolated from the patient's peripheral blood through leukapheresis. (2) These cells are activated using anti-CD3/CD28 antibodies to stimulate their proliferation. (3) Genetic ...