It took less than an hour to realize something had gone terribly wrong. In March 2006, six healthy volunteers of a Phase I clinical trial who had received a single infusion of the CD28 ...

Cancer immunotherapy has represented a significant advancement in cancer treatment; however, many patients experience relapse or develop resistance to this treatment. Bispecific antibodies that ...

Fig 1. Overview of the CAR-T cell therapy process, highlighting the sequential steps from leukapheresis to CAR-T cell infusion. (1) T cells are isolated from the patient's peripheral blood through ...

Conventionally, the first and second stimulation signals in vitro, simulating the process in vivo, are achieved using anti-CD3 antibody, anti-CD28 antibody, or CD3/CD28 magnetic beads, along with the ...