Barrett's esophagus is an acquired metaplastic abnormality in which the normal stratified squamous epithelium lining of the esophagus is replaced by an intestinal-like columnar epithelium.
Esophageal adenocarcinoma, a subtype of the disease that arises from Barrett's esophagus, a condition in which the cells lining the esophagus become abnormal, is one of the most common in the UK.