他们的研究成果《High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis》发表于《Cell Death Discovery》期刊。该研究首次运用单细胞核 RNA 测序（snRNA ...

The product of the BRCA1 gene — germline mutations in which confer an increased risk of breast or ovarian cancer — has been implicated in the repair of double-stranded DNA breaks (DSBs).

FANCJ, also known as BACH1 or BRIP1, was identified as a direct BRCA1-BRCT interacting protein and functions in DNA repair and checkpoint control. Bi-allelic inheritance of mutations in FANCJ ...

IMMvention is moving BACH1 inhibitors through preclinical development. The oral small molecules could induce fetal hemoglobin expression. Other companies have hit on the idea of treating sickle ...