Tiumbio Co Ltd. has described bromodomain-containing protein 4 (BD2 domain) (BRD4 BD2) inhibitors reported to be useful for the treatment of cancer, fibrosis, diabetes, metabolic syndrome, and renal ...

Investigators at the Third People’s Hospital of Chengdu and collaborators described the synergistic effect obtained by the combined administration of LB-23, a PARP1 degrader, and JQ1, a BRD4 inhibitor ...

a team led by experts at Cincinnati Children's reports that mice induced to develop brain tumors featuring fused proteins survived longer when treated with BRD4 inhibitors.

When BRD4 was removed from cells, BET inhibitors completely killed cancer cells. They also discovered that BRD4 interacts with a protein complex called Mediator, which plays a major role in gene ...

By targeting the ACLY-BRD4 pathway, the researchers were able to suppress inflammation responses in aged mice, highlighting ...