Drugs that specifically inhibit BCR signaling elements are currently ... novel therapeutic strategies for the management of B-CLL. B-cell receptor-activation pathways following antigenic stimulation.

Figure 4: Impaired antigen receptor–activated B cell proliferation and humoral responses in Vav-deficient mice. Figure 5: Vav-2 in BCR signaling and tyrosine phosphorylation in Vav-1 −/− Vav ...

In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell ...

Dr. David A. Braun delved into the molecular factors which drive exceptional responses to immunotherapy in metastatic clear cell renal cell carcinoma.

Signaling by type I cytokines involves the formation of receptor homodimers, heterodimers or higher order receptor oligomers. Here we report the cloning of a type I cytokine receptor subunit that ...

One avenue for this ambition is cell receptors, which function like ignition slots on a cell, requiring keys—such as specific hormones, drugs, or antigens—to start up specific cellular activities.

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel ...