Over time, the disease can also affect memory and lead to dementia. A similar condition called Lewy Body Dementia (LBD), ...

Because p62, one of the adaptors involved in directing substrates for autophagic degradation, has a ubiquitin-binding domain, researchers focused on ubiquitin as a sorting signal in autophagy.

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

According to the findings, the p62 protein, which plays a crucial role in the cell's autophagy process, is abundant in micronuclei and affects their stability. Similar to the companion study ...