For example, at the first Keystone Symposium on Autophagy in Health and Disease, held in 2007, Seiji Kondo noted that in the field of cancer research, his colleagues' response when discussing the ...

引言衰老是生物体经历的系统性功能衰退过程，与神经退行性疾病、代谢失调和癌症等年龄相关疾病密切相关。蛋白质稳态（proteostasis）的丧失是衰老的重要分子特征之一，而自噬（autophagy）在维持细胞稳态及调节蛋白质降解过程中起核心作用。自噬主 ...

Autophagy has been linked to inflammatory bowel disease. Studies of two different mouse strains deficient in the autophagy-related gene product Atg16L1 now show that autophagy is important in ...

As a result, autophagy is a fundamental defense mechanism employed by cells to control and ... a groundbreaking advancement in 3D cell culture technology designed to accelerate drug discovery and ...

In a recent study published in the journal Neuron, researchers at the University of Cambridge and Newcastle University, UK, examined the relationship between autophagy, aging, and neurodegeneration.

In the mid-1950s, Sam Clark Jr. of the School of Medicine at Washington University in St. Louis looked through his electron microscope at newborn-mouse kidneys and spotted something he’d never seen ...

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste.

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

The study, which was conducted within the framework of the Collaborative Research Centre 1451 "Key Mechanisms of Motor Control in Health and Disease," highlights the pivotal role of autophagy ...

Parkinson’s disease is a brain disorder that affects movement, making everyday tasks difficult for nearly one million people ...

More information: Suhyun Kim et al, Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in ...