In response to various injuries, TGFb is released from different types of cells, such as macrophages engulfing apoptotic hepatocytes. Then, TGFb induces the production of FGF18 in HSCs and ...

Hepatocytes display heterogeneity along the ... Decreased deoxyribonuclease I activity also plays a crucial role by reducing ...

The 'canonical principle' of fibrogenesis starts with necrosis or apoptosis of hepatocytes and inflammation-connected activation of hepatic stellate cells (HSC), their transdifferentiation to ...

It has been proposed that the suppression of Fas-mediated death of hepatocytes that express ... to the development of persistent infection. The apoptotic death of immune effector cells can also ...

release from necrotic hepatocytes and reduced hepatic clearance Inhibition of TGF-β, blockade of intracellular signalling BMP-7 TGF-β antagonist: anti-apoptotic; anti-inflammatory; anti-EMT ...