In response to various injuries, TGFb is released from different types of cells, such as macrophages engulfing apoptotic hepatocytes. Then, TGFb induces the production of FGF18 in HSCs and ...

The test detects the enhanced hepatocyte-cell death that accompanies NASH. Levels of a particular cleaved fragment of cytokeratin 18 (CK-18), produced during an apoptotic cell death pathway in the ...

Hepatocytes display heterogeneity along the ... Decreased deoxyribonuclease I activity also plays a crucial role by reducing ...