2022). How genetic ancestry modifies the effects of AD susceptibility loci beyond the APOE4 and APOE2 alleles has also been examined. Interestingly, an analysis of whole genome data from the Alzheimer ...

Late-onset Alzheimer's disease is a debilitating, progressive neurodegenerative disease that affects about 7 million Americans, a figure that is expected to nearly double by 2050, according to the ...

Studies on genetic variations regarding the APOE alleles, GABA and Na–K–Cl cotransporter 1 are required. Specific pharmacological agents, such as bumetanide, need development. More studies ...

The APOE gene comes in several different forms, or alleles. APOE3 is the most common and is not believed to affect Alzheimer's risk, while the rare APOE2 may even protect people from Alzheimer's.