Hosted on MSN9mon
Study reveals that almost all individuals with two copies of the APOE4 gene develop signs of Alzheimer's
In this work, researchers evaluated clinical, pathological, and biomarker changes in APOE4 homozygotes to determine their risk of developing Alzheimer's disease. They used data from 3,297 brain ...
Hosted on MSN9mon
Alzheimer's Variant May Cause Distinct Form of the Disease
The APOE4 variant may be more than just a genetic risk factor for Alzheimer's disease, new data from several cohorts suggested. Clinical, pathological, and biomarker changes indicated that APOE4 ...
Nature9d
Apolipoprotein E4 and Sex Affect Neurobehavioral Performance in Primary School Children
Apolipoprotein E4 (apoE4) and female sex are risk factors for developing Alzheimer's disease. It is unclear whether apoE4 contributes to behavioral function at younger ages. Standard ...
ALZFORUM2y
APOE Region
Although APOE4 and APOE2 were the index variants for most associations ... expression levels of APOE and TOMM40 were higher in homozygotes with very long TOMM40-523 poly-T repeats compared with ...
EurekAlert!9mon
Dr. Juan Fortea (IMAGE)
Researchers from the Research Area on Neurological Diseases, Neuroscience, and Mental Health at the Sant Pau Research Institute, led by Dr. Juan Fortea, Director of the Memory Unit of the ...
Nature8y
Metabolic shifts toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4
The Apolipoprotein E (APOE) gene encodes for three isoforms in the human population (APOE2, APOE3 and APOE4). Whereas the role of APOE in lipid metabolism is well characterized, the specific ...