来自MSN9 个月
Study reveals that almost all individuals with two copies of the APOE4 gene develop signs ...
In this work, researchers evaluated clinical, pathological, and biomarker changes in APOE4 homozygotes to determine their risk of developing Alzheimer's disease. They used data from 3,297 brain ...
生物通12 天
APOE4和久坐生活方式协同损害清醒小鼠视觉皮层的神经血管功能
生活方式与遗传性阿尔茨海默病的风险有关：老鼠血管和神经元的体内成像显示，当神经元活跃、老鼠运动较少时，APOE4在已经紧张的系统中最能降低神经血管功能。 APOE4 基因与生活方式对神经血管功能的协同影响研究解读 英国萨塞克斯大学心理学与萨塞克斯 ...
ALZFORUM2 年
APOE Region
Although APOE4 and APOE2 were the index variants for most associations ... For example, in the temporal and occipital cortices of both controls and AD cases, expression levels of APOE and TOMM40 were ...
Nature8 天
Apolipoprotein E4 and Sex Affect Neurobehavioral Performance in Primary School Children
Apolipoprotein E4 (apoE4) and female sex are risk factors for developing Alzheimer's disease. It is unclear whether apoE4 contributes to behavioral function at younger ages. Standard ...
来自MSN9 个月
Alzheimer's Variant May Cause Distinct Form of the Disease
The APOE4 variant may be more than just a genetic risk factor for Alzheimer's disease, new data from several cohorts suggested. Clinical, pathological, and biomarker changes indicated that APOE4 ...