SRC1 was the first cloned steroid receptor co-activator that interacts with steroid hormone receptors to promote transcriptional activation in a hormone-dependent manner. The p160 SRC family ...

Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor targeting moiety through a linker acting as androgen ...

The standard first-line treatment for patients with prostate cancer involves repressing the main driver of prostate cancer—the androgen receptor ... a transcriptional coactivator and regulator ...

In a video interview, William K. Oh, MD, director of precision medicine at Yale Cancer Center and Smilow Cancer Hospital discusses the latest breakthroughs in advanced prostate cancer treatment.

The androgen receptor (AR) plays a critical role in prostate cancer (PCa) development and progression. Despite the success of androgen-deprivation therapy, remission occurs in almost all cases.

These included genetic models such as androgen receptor knockout mice and chronic androgen exposure in females using dihydrotestosterone (DHT) implants. Subsequently, they analyzed DNA from ...