An isogenic cell line was created to model cancer patients with the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion oncogene and tested for its ...

Receptors such as EGFR, HER2, MET and ALK interface with common downstream signaling pathways and 'addiction switching' can occur, either by the inhibition of one receptor triggering a switch to ...

MAPK-ERK pathway: A signaling pathway that regulates various cellular processes, including growth and differentiation, and is often implicated in cancer. ALK inhibitors: Targeted therapies that ...