Prion diseases are characterized by abnormal folding of the host’s naturally-occurring prion protein, leading to rapid neurodegeneration. They can be genetic, sporadic—without known cause—or acquired, ...
CWD is also categorized as a prion disease, meaning it affects the brain’s prion proteins. When abnormal versions of these proteins infect the animal, they cause normal prion proteins to fold ...
The project aims to develop drugs which interacts with the biosynthetic pathway of prion protein either to stabilise its conformation or to provoke the interaction of the protein with its abnormal ...
But in deer with CWD, diseased prions fold in abnormal shapes and accumulate throughout the animals' nervous system, including the brain — causing weight loss, an unsteady gait, diminished fear ...
Prions are proteins that act like "seeds" of disease, explained Live Science, causing healthy proteins to "fold in abnormal, harmful ways". The new findings indicate parallels between the ...