Whereas poly-ADP-ribosylation generates a PTM that is highly dynamic, of variable length and with a branched, complex structure, the mono-ADP-ribosylation of specific side chains in target ...

Measuring cellular poly ADP-ribosylation can unlock new anticancer strategies and approaches. ADP-ribosylation, the attachment of ADP-ribose to proteins, is a common eukaryotic post-translational ...

In the Carter-O'Connell lab we are focused on using biochemistry to uncover the role of ADP-ribosylation in both normal human physiology (cell development, signal transduction, gene regulation) and ...